The Benchmark domestic equity indices, Sensex and Nifty, were trading over 0.4 per cent down in the forenoon trade today amid mixed global cues. On the sectoral front, barring Pharma, healthcare, media and telecommunication, all other sectors were trading with cuts. The 30-share BSE Sensex lost 377 points to 82,138 and the NSE Nifty50 slipped 110 points to 25,031, when reports last came in.